FITC标记的肿瘤坏死因子配体超家族成员15抗体
产品名称： FITC标记的肿瘤坏死因子配体超家族成员15抗体
英文名称： Anti-TNFSF15/FITC
产品编号： HZ-19940R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TNFSF15/FITC Conjugated antibody
FITC标记的肿瘤坏死因子配体超家族成员15抗体
| 英文名称 | Anti-TNFSF15/FITC |
| 中文名称 | FITC标记的肿瘤坏死因子配体超家族成员15抗体 |
| 别 名 | TL1A; TL1 A; TL 1A; TL-1A; tl1; tl1a; tnf ligand related molecule 1; TNF ligand-related molecule 1; tnf superfamily ligand tl1a; TNF15_HUMAN; Tumor necrosis factor ligand superfamily member 15; Vascular endothelial cell growth inhibitor; Vascular endothelial growth inhibitor 192a; Vascular endothelial growth inhibitor; vegi; VEGI192A antibodysecreted form; MGC129934; MGC129935. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 28kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TNFSF15 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] Function: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Subunit: Homotrimer. Subcellular Location: Secreted and Membrane. Tissue Specificity: Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. Similarity: Belongs to the tumor necrosis factor family. Database links: Entrez Gene: 9966 Human Entrez Gene: 326623 Mouse Entrez Gene: 252878 Rat Omim: 604052 Human SwissProt: O95150 Human SwissProt: Q5UBV8 Mouse SwissProt: Q8K3Y7 Rat Unigene: 241382 Human Unigene: 208152 Mouse Unigene: 84873 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白质是属于肿瘤坏死因子（TNF）配体家族的细胞因子。该蛋白在内皮细胞中大量表达，但在B细胞或T细胞中均未表达。这种蛋白的表达是由TNF和IL-1α诱导的。该细胞因子是受体TNFRSF25和诱骗受体TNFRSF21/DR6的配体。它可以激活NF-κB和MAP激酶，并作为自分泌因子诱导内皮细胞凋亡。还发现该细胞因子抑制内皮细胞增殖，因此可以作为血管生成抑制剂发挥作用。发现了两个编码不同亚型的转录变体。[ RefSeq，FEB 2011 ]提供