FITC标记的信号转导和转录激活因子7抗体
产品名称： FITC标记的信号转导和转录激活因子7抗体
英文名称： Anti-SOCS7/FITC
产品编号： HZ-20151R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SOCS7/FITC Conjugated antibody
FITC标记的信号转导和转录激活因子7抗体
| 英文名称 | Anti-SOCS7/FITC |
| 中文名称 | FITC标记的信号转导和转录激活因子7抗体 |
| 别 名 | NAP 4; NAP 4 Fragment; NAP4; Nck Ash and phospholipase C binding protein; Nck Ash and phospholipase C gamma binding protein; Nck associated protein 4; NCKAP4; SH2 domain containing SOCS box protein; SOCS 7; SOCS4; SOCS6; Suppressor of cytokine signaling 7;SOCS7_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 63kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SOCS7 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes. SOCS6 and SOCS7 are expressed ubiquitously in murine tissues and SOCS6 knockout mice are growth retarded. Function: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Subunit: Interacts with phosphorylated IRS4 and PIK3R1 (By similarity). Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6. Subcellular Location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence. Tissue Specificity: Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain. Similarity: Contains 1 SH2 domain. Contains 1 SOCS box domain. Database links: Entrez Gene: 30837 Human Omim: 608788 Human SwissProt: O14512 Human SwissProt: Q8WXH5 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
最近发现的细胞因子信号抑制因子（SOCS）家族的八个成员是SOCS1、SOCS2、SOCS3、SOCS4、SOCS5、SOCS6、SOCS7和CIS。在结构上，SOCS蛋白由长度和氨基酸组成的N端区、中心SH2结构域和称为SOCS盒的C端基序组成。SOCS蛋白似乎是调节细胞因子信号转导的经典负反馈回路的一部分。每个SOCS基因的转录在体外和体内响应于细胞因子迅速发生，并且一旦产生，SOCS家族的各个成员似乎以不同的方式抑制信号传导。当SOCS1和SOCS6在人肝癌细胞（HepG2）或大鼠肝癌细胞中表达时，它们与胰岛素受体（IR）相互作用。SOCS1和SOCS6在体内抑制ERK1/2和蛋白激酶B的胰岛素依赖性激活，在体外抑制IRS1的红外定向磷酸化。这些结果提示，SOCS蛋白可能是IR信号传导的抑制剂，可介导细胞因子诱导的胰岛素抵抗，参与II型糖尿病的发病过程。SOCS6和SOCS7在小鼠组织中普遍表达，SOCS6基因敲除小鼠生长发育迟缓。