分子量:42.6 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human Frizzled-5, Fc Tag by the LAL method.

Buffer:PBS, pH 7.4

生物活性:

产品特性:Human Frizzled-5, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 42.6 kDa. The predicted N-terminus is Ala 27. The reducing (R) protein migrates as 55-60 kDa in SDS-PAGE  due to glycosylation.

产品背景:Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.