FITC标记的白细胞介素10抗体
产品名称： FITC标记的白细胞介素10抗体
英文名称： Anti-IL-10/FITC
产品编号： HZ-20373R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-IL-10/FITC Conjugated antibody
FITC标记的白细胞介素10抗体
| 英文名称 | Anti-IL-10/FITC |
| 中文名称 | FITC标记的白细胞介素10抗体 |
| 别 名 | Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 20kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-10 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: IL-10 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Function: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Subunit: Homodimer. Subcellular Location: Secreted. Tissue Specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types. Similarity : Belongs to the IL-10 family. Database links: Entrez Gene: 3586 Human Entrez Gene: 16153 Mouse Entrez Gene: 25325 Rat Omim: 124092 Human SwissProt: P22301 Human SwissProt: P18893 Mouse SwissProt: P29456 Rat Unigene: 193717 Human Unigene: 874 Mouse Unigene: 9868 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 白细胞介素-10(IL-10)是主要由Th2细胞所产生的一种细胞因子，活化的B细胞、单核巨噬细胞和枯否氏细胞（Kupffer's cell）等也可产生IL-10。它是以抑制Th细胞克隆细胞因子合成为特点的多效免疫调节因子。 白介素-10是维护细胞因子网络平衡的重要负调节因子。其作用机制可能是降低抗原递呈细胞MHCⅡ类抗原表达，或诱导抗原递呈细胞产生另一种细胞因子，改变细胞内信号传递途径，从而选择性抑制某些细胞因子mRNA转录，并与Th2细胞产生的IL-4、IL-5有协同作用 |
IL-10蛋白是一种主要由单核细胞产生的细胞因子，在一定程度上由淋巴细胞产生。这种细胞因子在免疫调节和炎症中具有多效性作用。它下调了巨噬细胞上Th1细胞因子、MHCⅡ类抗原和共刺激分子的表达。它还能增强B细胞的存活、增殖和抗体的产生。该细胞因子可阻断NF-κB活性，参与JAK-STAT信号通路的调节。在小鼠中进行的敲除研究表明这种细胞因子在肠道中作为必需的免疫调节剂的功能。