CRCP,降钙素基因相关肽受体CRCP抗体

产品编号HZ-14048R
英文名称CRCP
中文名称降钙素基因相关肽受体CRCP抗体
别 名Calcitonin gene related peptide receptor component; Calcitonin gene related peptide receptor component protein; Calcitonin gene-related peptide-receptor component protein; CGRP receptor component protein; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; CRCP; DNA-directed RNA polymerase III subunit RPC9; HsC17; RCP; RCP9; RNA polymerase III subunit C9; RPC9_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 细胞膜受体 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
CRCP,降钙素基因相关肽受体CRCP抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量21kDa
细胞定位细胞核 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CRCP
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CRCP,降钙素基因相关肽受体CRCP抗体PubMedPubMed
产品介绍background:
This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.

Subcellular Location:
Nucleus. Cell membrane.

Tissue Specificity:
Ubiquitous. Most prevalent in testis.

Similarity:
Belongs to the eukaryotic RPC9 RNA polymerase subunit family.

Gene ID:
27297

CRCP,降钙素基因相关肽受体CRCP抗体Database links:
Entrez Gene: 27297 Human
Omim: 606121 Human
SwissProt: O75575 Human
Unigene: 300684 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.