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Glutamate Carboxypeptidase-Like Protein 2 ( CNDP1 / CN1 ) Antibody
 
 
 
CNDP1 / CN1抗体产品信息
 
 
 
 
免疫原 : 
 
 
Human cell-derived rhCNDP1 ( Catalog#10077-H08H )
 
 
 
 
 
Clone ID :
 
 
 
5E11B6G5
 
 
 
 
抗体宿主 :
 
 
Mouse IgG1
 
 
 
 
缓冲液 :
 
0.2 μm filtered solution in PBS with 5% trehalose
 
 
 
制备方法 : 
 
 
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human Carnosine Dipeptidase 1 (rhCNDP1; Catalog#10077-H08H; aa 27-508; NP_116038.4). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
 
 
 
 
 
CNDP1 / CN1抗体使用指南
 
 
 
 
特异性 : 
 
 
Human CNDP1 / CN1
 
 
 
 
 
 
 
No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA.
 
 
 
 
Western blot : 
 
This antibody can be used at 1-2μg/mL with the appropriate secondary reagents to detect CNDP1 in WB.
 
 
 
储存方法 :
 
This antibody can be stored at 2℃-8℃ for 1 month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
 Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly.
 Avoid repeated freeze-thaw cycles.
 
 
 
 
CNDP1 / CN1 Antibody Related Products & Topics
 
 
相关研究领域:
 
Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>CNDP1
 
蛋白:
 
 
 
 
Molecule
 
Species
 
Description //For Detailed Info.------CLICK!
 
Cat No
 
 
 
CNDP1
 
Human
 
CNDP1/Fc Protein, Recombinant 
 
10077-H03H
 
 
 
CNDP1
 
Human
 
CNDP1 Protein, Recombinant 
 
10077-H08H
 
 
 
 
抗体:
 
 
 
 
Molecule
 
Application
 
Description //For Detailed Info.------CLICK!
 
Cat No
 
 
 
Human 
 CNDP1
 
ELISA
 
Mouse Monoclonal Antibody
 
10077-MM01
 
 
 
Human 
 CNDP1
 
WB
 
Mouse Monoclonal Antibody
 
10077-MM02
 
 
 
Human 
 CNDP1
 
ELISA
 
Rabbit Polyclonal Antibody
 
10077-RP03
 
 
 
Human 
 CNDP1
 
WB, ELISA
 
Rabbit Polyclonal Antibody (Antigen Affinity Purified)
 
10077-RP04
 
 
 
 
 
 CNDP1 / CN1 Antibody Background
 
 
CNDP1, also known as glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. This protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine, and is identified as human carnosinase expressed in the brain. The CN1 gene contains trinucleotide (CTG) repeat length polymorphism in the coding region, which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy, for carnosine protects against the adverse effects of high glucose levels on renal cells. In addition, this protein is also suggested to be implicated in the actions of neuroprotection and neurotransmiting.   
 
 
参考文献
 
 
1. Teufel, Mm. et al., 2004, J. Biol. Chem. 278 : 6521-6532.
 
2. Riedl, E. et al., 2007, Diabetes. 56: 2410-2413.
 
3. Sauerhofer, S. et al., 2007, Diabetes. 56: 2425-2432.
 
 
 
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