IBA1抗体
Applications
| In-house applications |
ELISA, WB, IP, IHC, IF Application not tested? Please see our Guarantee. |
| Published applications |
IF, IHC, WB |
Publications |
25 citations –view here |
| Species specificity |
Human,Mouse,Rat; other species not tested. |
| Published Species |
Human, mouse, rat |
|
Images
Prev12Next
 mouse spleen tissue were subjected to SDS PAGE followed by western blot with 10904-1-AP(IBA1 antibody) at dilution of 1:1000 Immunohistochemical of paraffin-embedded human brain using 10904-1-AP(IBA1 antibody) at dilution of 1:50 (under 10x lens) Immunohistochemical of paraffin-embedded human brain using 10904-1-AP(IBA1 antibody) at dilution of 1:50 (under 40x lens) Immunofluorescent analysis of ( -20℃ Ethanol ) fixed C6 cells using 10904-1-AP( IBA1 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) IP Result of anti-IBA1 (IP:10904-1-AP, 3ug; Detection:10904-1-AP 1:500) with U-937 cells lysate 3000ug.
|
| Positive WB detected in |
Mouse spleen tissue, rat spleen tissue |
| Positive IP detected in |
U-937 cells |
| Positive IHC detected in |
Human brain tissue, human lymphoma tissue, human tonsillitis tissue |
| Positive IF detected in |
C6 cells, HepG2 cells |
| Recommended dilution |
WB : 1:500-1:5000
IP : 1:200-1:2000
IHC : 1:20-1:200
IF : 1:50-1:500 |
IBA1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information IBA1抗体
| Immunogen |
IBA1 fusion protein ag1363 |
Full name |
Allograft inflammatory factor 1 |
Calculated molecular
weight |
17 kDa |
Observed molecular
weight |
17 kDa |
GenBank accession
number |
BC009474 |
Gene ID (NCBI) |
199 |
| Gene symbol |
AIF1 |
Synonyms |
AIF 1, AIF1, G1, IBA1, IRT 1, Protein G1 |
Background
|
AIF1, also named as G1, IBA1 or daintain/AIF-1, is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vascular inflammation. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. It is also as a microglial cell marker. IBA1抗体
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