ADORA1 Pre-design Chimera RNAi
产品名称： ADORA1 Pre-design Chimera RNAi
英文名称： ADORA1 Pre-design Chimera RNAi
产品编号： H00000134-R02
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Homo sapiens adenosine A1 receptor (ADORA1), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_000674
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 134
- Gene Name:
- ADORA1
- Gene Alias:
- RDC7
- Gene Description:
- adenosine A1 receptor
- Omim ID:
- 102775
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000039090,OTTHUMP00000039091
- Gene Pathway
- Related Disease
- Anorexia Nervosa
- Asthma
- Asthma
- Brain Injuries
- Bulimia
- Cardiomyopathies
- Cardiovascular Diseases
- Depressive Disorder, Major
- Diabetes Mellitus, Type 2
- Drug Hypersensitivity
- Drug Toxicity
- Edema
- Epilepsy, Post-Traumatic
- Fatigue
- Genetic Predisposition to Disease
- Hypercholesterolemia
- Hypertension
- Myocardial Infarction
- Myocardial Ischemia