FITC标记的p53诱导蛋白3抗体
产品名称： FITC标记的p53诱导蛋白3抗体
英文名称： Anti-PIG3/FITC
产品编号： HZ-6143R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-PIG3/FITC Conjugated antibody
FITC标记的p53诱导蛋白3抗体
| 英文名称 | Anti-PIG3/FITC |
| 中文名称 | FITC标记的p53诱导蛋白3抗体 |
| 别 名 | p53 induced gene 3 protein; p53-induced gene 3 protein; Putative quinone oxidoreductase; quinone oxidoreductase homolog; TP53I3 ; tumor protein p53 inducible protein 3; Tumor protein p53-inducible protein 3; QORX_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 细胞凋亡 细胞周期蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PIG3/TP53I3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene (from EntrezGene). Function: May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). Subunit: Homodimer. Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. Database links: UniProtKB/Swiss-Prot: Q53FA7.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码的蛋白质与氧化还原酶相似，氧化还原酶是参与细胞对氧化应激和辐射反应的酶。该基因是由肿瘤抑制因子p53诱导的，并被认为参与p53介导的细胞死亡。它包含在其启动子区域中的p53共识结合位点和下游的五核苷酸微卫星序列。p53已被证明通过与下游的五核苷酸微卫星序列相互作用转录激活该基因。微卫星是多态性的，具有不同数量的五核苷酸重复与p53的转录激活程度直接相关。有人认为微卫星多态性可能与癌症的易感性相关。至少有两个编码相同蛋白的转录变体被发现（来自Enter基因）。