FITC标记的G氨基丁酸受体δ/GABAA Rδ抗体
产品名称： FITC标记的G氨基丁酸受体δ/GABAA Rδ抗体
英文名称： Anti-GABRD/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GABRD/FITC Conjugated antibody
FITC标记的G氨基丁酸受体δ/GABAA Rδ抗体
| 英文名称 | Anti-GABRD/FITC |
| 中文名称 | FITC标记的G氨基丁酸受体δ/GABAA Rδ抗体 |
| 别 名 | GABA A Receptor delta; GABA(A) receptor subunit delta; GABRD; Gamma aminobutyric acid GABA A receptor delta; Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor; Gamma-aminobutyric acid receptor subunit delta; GBRD_HUMAN; MGC45284. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 细胞膜受体 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GABRD |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho Subcellular Location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. DISEASE: Defects in GABRD are the cause of susceptibility to generalized epilepsy with febrile seizures plus type 5 (GEFS+5) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. Defects in GABRD are the cause of susceptibility to idiopathic generalized epilepsy type 10 (IGE10) [MIM:613060]. A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in GABRD are the cause of susceptibility to juvenile myoclonic epilepsy type 7 (EJM7) [MIM:613060]. A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily. Database links: Entrez Gene: 2563 Human Entrez Gene: 14403 Mouse Entrez Gene: 29689 Rat Omim: 137163 Human SwissProt: O14764 Human SwissProt: P22933 Mouse SwissProt: P18506 Rat Unigene: 113882 Human Unigene: 388925 Mouse Unigene: 10927 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
γ-氨基丁酸（GABA）是哺乳动物大脑中主要的抑制性神经递质，它作用于GABA-A受体，这些受体是配体门控氯通道。这些通道的氯离子传导可以由与GABA A受体结合的二氮卓类药物调节。GABA A受体一般为五聚体，有五种亚基：α、β、γ、δ和Rho。该基因编码δ亚基。该基因的突变与5型热性惊厥的全身性癫痫易感性有关。已经描述了该基因的另一种剪接转录体变体，但尚未确定其生物有效性。[ RefSeq，JUL 2008 ]