分子量:27.1 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Cynomolgus PD-L1, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Cynomolgus PD-L1, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 27.1 kDa. The predicted N-terminus is Phe 19. The reducing (R) protein migrates as 35-40 kDa in SDS-PAGE  due to glycosylation.

产品背景:Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.