CDKN1A (phospho T57) Peptide
产品名称: CDKN1A (phospho T57) Peptide
英文名称: CDKN1A (phospho T57) Peptide
产品编号: P1372
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of CDKN1A.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T57 of human CDKN1A.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia.
Scott SA, Kimura T, Dong WF, Ichinohasama R, Bergen S, Kerviche A, Sheridan D, DeCoteau JF.Leuk Res. 2004 Dec;28(12):1293-301.
- 2.
- Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent.
Chen T, Turner J, McCarthy S, Scaltriti M, Bettuzzi S, Yeatman TJ.Cancer Res. 2004 Oct 15;64(20):7412-9.
- 3.
- Interplay between HIV-1 Vpr and Sp1 modulates p21(WAF1) gene expression in human astrocytes.
Amini S, Saunders M, Kelley K, Khalili K, Sawaya BE.J Biol Chem. 2004 Oct 29;279(44):46046-56. Epub 2004 Aug 9.
- Applications
- Western Blot (Tissue lysate)
- CDKN1A (phospho T57) polyclonal antibody (Cat # PAB0556). Western blot analysis of CDKN1A expression in human colon.
- Protocol Download
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with CDKN1A (phospho T57) polyclonal antibody (Cat # PAB0556) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 1026
- Protein Accession#:
- NP_000380;P38936
- Gene Name:
- CDKN1A
- Gene Alias:
- CAP20,CDKN1,CIP1,MDA-6,P21,SDI1,WAF1,p21CIP1
- Gene Description:
- cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- Omim ID:
- 116899
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq
- Other Designations:
- CDK-interaction protein 1,DNA synthesis inhibitor,OTTHUMP00000016298,cyclin-dependent kinase inhibitor 1A,melanoma differentiation associated protein 6,wild-type p53-activated fragment 1
- Interactome
- Related Disease
- Adenocarcinoma
- Ataxia telangiectasia
- Atherosclerosis
- Atherosclerosis
- Bowen's Disease
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Basal Cell
- Carcinoma, Squamous Cell
- Carcinoma, Transitional Cell
- Cardiovascular Diseases
- Chromosome Aberrations
- Chronic Disease
- Colorectal Neoplasms
- Diabetes Mellitus, Type 2
- Disease Progression
- DNA Damage