FITC标记的CXXC型锌指蛋白4抗体
产品名称： FITC标记的CXXC型锌指蛋白4抗体
英文名称： Anti-CXXC4/FITC
产品编号： HZ-14127R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CXXC4/FITC Conjugated antibody
FITC标记的CXXC型锌指蛋白4抗体
| 英文名称 | Anti-CXXC4/FITC |
| 中文名称 | FITC标记的CXXC型锌指蛋白4抗体 |
| 别 名 | CXXC finger 4; CXXC finger protein 4; CXXC type zinc finger protein 4; CXXC-type zinc finger protein 4; Cxxc4; CXXC4_HUMAN; Dvl binding protein IDAX (inhibition of the Dvl and Axin complex); IDAX; Inhibition of the Dvl and axin complex protein; MGC149872. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 锌指蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 21kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CXXC4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Idax is a 198 amino acid cytoplasmic protein that functions as a negative regulator of the Wnt signaling pathway through its interaction with the PDZ domain of Dvl-1. Containing one CXXC-type zinc finger, Idax is expressed at high levels in brain, with lower levels in testis and thymus. The gene encoding Idax maps to human chromosome 4, which represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Function: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1. Subcellular Location: Cytoplasm. Similarity: Contains 1 CXXC-type zinc finger. Database links: Entrez Gene: 80319 Human Entrez Gene: 319478 Mouse Entrez Gene: 83824 Rat SwissProt: Q9H2H0 Human SwissProt: Q6NXI8 Mouse SwissProt: Q9EQC9 Rat Unigene: 12248 Human Unigene: 224814 Mouse Unigene: 442744 Mouse Unigene: 457442 Mouse Unigene: 209562 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Idax是一个198个氨基酸的胞浆蛋白，作为Wnt通过DVL-1的PDZ结构域相互作用的信号转导通路的负调节。含有一个CXXC型锌指，Idax在大脑中高表达，睾丸和胸腺的水平较低。编码Idax映射到人类4号染色体上的基因，约6%的人类基因组包含近900个基因。值得注意的是，亨廷顿基因，并发现编码扩大谷氨酰胺道在亨廷顿病例，是4号染色体上。FGFR-3也是4号染色体上编码并有致死性侏儒、软骨发育不全有关，Muenke综合征与膀胱癌。第4号染色体也与Ellis van Creveld综合征、甲基丙二酸血症和多囊肾病有关。