FOLH1 monoclonal antibody, clone Y/PSMA1
产品名称: FOLH1 monoclonal antibody, clone Y/PSMA1
英文名称: FOLH1 monoclonal antibody, clone Y/PSMA1
产品编号: MAB4315
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native FOLH1.
- Immunogen:
- Native purified FOLH1 from pooled human prostate adenocarcinoma tissues.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- Prostate specific membrane antigen, extracellular domain. Reacts with human prostate carcinoma tissues and PSMA derived synthetic peptides. Does not react against normal human prostate tissues or to benign prostatic hyperplasia (BPH) tissues. Reactive to PSMA expressed LNCap cell lines.
- Form:
- Lyophilized
- Isotype:
- IgG2b, kappa
- Storage Buffer:
- Lyophilized from 10 mM PBS, pH 7.0
- Storage Instruction:
- Store at -20°C on dry atmosphere.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- PSMA mimotope isolated from phage displayed peptide library can induce PSMA specific immune response.
Zhu ZY, Zhong CP, Xu WF, Lin GM, Ye GQ, Ji YY, Sun B, Yeh M.Cell Res. 1999 Dec;9(4):271-80.
- Application Image
- Western Blot
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry (Frozen sections)
- Immunofluorescence
- ELISA
- Entrez GeneID:
- 2346
- Gene Name:
- FOLH1
- Gene Alias:
- FGCP,FOLH,GCP2,GCPII,NAALAD1,NAALAdase,PSM,PSMA,mGCP
- Gene Description:
- folate hydrolase (prostate-specific membrane antigen) 1
- Omim ID:
- 600934
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq
- Other Designations:
- N-acetylated alpha-linked acidic dipeptidase 1,cell growth-inhibiting protein 27,folate hydrolase 1,folylpoly-gamma-glutamate carboxypeptidase,glutamate carboxylase II,glutamate carboxypeptidase II,membrane glutamate carboxypeptidase,prostate specific mem
- Related Disease
- Aortic Aneurysm, Abdominal
- Atherosclerosis
- Brain Ischemia
- Cardiovascular Diseases
- Chromosome Aberrations
- Cleft Lip
- Cleft Palate
- Cognition
- Colorectal Neoplasms
- Coronary Disease
- Diabetes Mellitus, Type 2
- DNA Damage
- Edema
- Genetic Predisposition to Disease
- Hyperhomocysteinemia
- Hypertension
- Kidney Failure, Chronic
- Micronuclei, Chromosome-Defective
- Neural Tube Defects