分子量:25 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human Azurocidin, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human Azurocidin, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 25 kDa. The predicted N-terminus is Ile 27. The reducing (R) protein migrates as 32-40 kDa in SDS-PAGE  due to glycosylation.

产品背景:Azurocidin (AZU1) is also known as Heparin-binding protein (HBP), Cationic antimicrobial protein CAP37, is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. which belongs to the peptidase S1 family and elastase  subfamily. AZU1 / HBP contains 1 peptidase S1 domain. AZU1 binds heparin. The cytotoxic action of AZU1 is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. AZU1 may play a role in mediating recruitment of monocytes in the second wave of inflammation.