ADRA2A Pre-design Chimera RNAi
产品名称： ADRA2A Pre-design Chimera RNAi
英文名称： ADRA2A Pre-design Chimera RNAi
产品编号： H00000150-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Homo sapiens adrenergic, alpha-2A-, receptor (ADRA2A), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_000681
- Target Region:
- 3' Untranslated Region (3'UTR)
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 150
- Gene Name:
- ADRA2A
- Gene Alias:
- ADRA2,ADRA2R,ADRAR,ALPHA2AAR,ZNF32
- Gene Description:
- adrenergic, alpha-2A-, receptor
- Omim ID:
- 104210
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq
- Other Designations:
- OTTHUMP00000058849,alpha-2-adrenergic receptor, platelet type,alpha-2A adrenoceptor,alpha-2A-adrenergic receptor,alpha-2AAR subtype C10,alpha2A adrenergic receptor
- Gene Pathway
- Related Disease
- Acute Disease
- Alcoholism
- Alzheimer Disease
- Alzheimer disease
- Anorexia Nervosa
- Attention
- Attention Deficit Disorder with Hyperactivity
- Autistic Disorder
- Body Weight
- Brief Psychiatric Rating Scale
- Bulimia
- Cardiovascular Diseases
- Choice Behavior
- Cognition
- Colitis, Ulcerative
- Constipation
- Depressive Disorder
- Depressive Disorder, Major
- Diabetes Complications