FITC标记的膜相关接头蛋白LAX抗体
产品名称： FITC标记的膜相关接头蛋白LAX抗体
英文名称： Anti-LAX1/FITC
产品编号： HZ-17111R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-LAX1/FITC Conjugated antibody
FITC标记的膜相关接头蛋白LAX抗体
| 英文名称 | Anti-LAX1/FITC |
| 中文名称 | FITC标记的膜相关接头蛋白LAX抗体 |
| 别 名 | FLJ20340; LAT like membrane associated protein; LAX; LAX1_HUMAN; Linker for activation of X cells; Lymphocyte transmembrane adaptor 1; Membrane associated adapter protein LAX; OTTHUMP00000034094. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 激酶和磷酸酶 淋巴细胞 t-淋巴细胞 b-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LAX1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: LAX1 is a 398 amino acid single-pass type III membrane protein that negatively regulates lymphocyte signaling. LAX1 is expressed in lymphoid tissues including thymus, spleen and peripheral blood leukocytes, along with several B-cell, T-cell, natural killer and monocyte cell lines. When stimulated by B or T cells, LAX1 becomes dramatically upregulated and also interacts with GRB2, Gads and PI 3-kinase p85 upon phosphorylation. LAX1 exists as two alternatively spliced isoforms that are encoded by a gene located on human chromosome 1. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Function: LAX1 negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. Subunit: When phosphorylated, interacts with GRB2, PIK3R1 and GRAP2. Subcellular Location: Cell Membrane; Single-pass type III membrane protein. Tissue Specificity: Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines. Post-translational modifications: Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation; which leads to the recruitment of GRB2, PIK3R1 and GRAP2. Database links: Entrez Gene: 54900 Human SwissProt: Q8IWV1 Human Unigene: 272794 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Lax1是398个氨基酸单通道Ⅲ型膜蛋白，负调节淋巴细胞信号传导。LAX1在包括胸腺、脾脏和外周血白细胞的淋巴组织中表达，同时在多种B细胞、T细胞、自然杀伤细胞和单核细胞系中表达。当受到B细胞或T细胞的刺激时，LAX1变得显著上调，并且在磷酸化时与GRB2、Gads和PI 3激酶p85相互作用。Lax1作为两个交替剪接的亚型存在，该亚型由位于人类1号染色体上的基因编码。染色体1包含许多疾病相关基因，包括那些与家族性腺瘤性息肉病、Stickler综合征、帕金森病、Gaucher病、精神分裂症和Usher综合征相关的基因。