FITC标记的FMS样酪氨酸激酶3配体抗体
产品名称： FITC标记的FMS样酪氨酸激酶3配体抗体
英文名称： Anti-FLT3L/FITC
产品编号： HZ-5905R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FLT3L/FITC Conjugated antibody
FITC标记的FMS样酪氨酸激酶3配体抗体
| 英文名称 | Anti-FLT3L/FITC |
| 中文名称 | FITC标记的FMS样酪氨酸激酶3配体抗体 |
| 别 名 | Flt 3 ligand; Flt 3L; Flt3 L; FLT3 LG; Flt3 ligand; Flt3L; FLT3L_HUMAN; FLT3LG; Fms related tyrosine kinase 3 ligand; Fms-related tyrosine kinase 3 ligand; SL cytokine. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 免疫学 干细胞 t-淋巴细胞 b-淋巴细胞 细胞因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FLT3L (101-150aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Flt 3 ligand (Flt 3-L), variously designated Flt 3/Flk 2 ligand or FL, is a hematopoietic growth factor that stimulates the proliferation of stem and CD34+ progenitor cells and has been cloned from both mouse and human genomes. Flt 3-L is a potent in vitro growth stimulator of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and G-CSF-dependent granulocyte-macrophage committed precursors from Lin CD34+ bone marrow cells as well as other primitive B cell populations. Additionally, Flt 3-L stimulates the proliferation of hematopoietic progenitor cells isolated from mouse fetal liver or adult mouse bone marrow. Flt 3-L does not, however, affect the growth of erythroid-committed progenitors. Flt 3-L exists in two forms and is active as both a soluble and as a membrane-bound ligand. The Flt 3-L receptor, Flt 3, is a tyrosine kinase expressed on CD34+ cells that shares a high degree of homology with the SCF (stem cell factor) receptor, c-Kit and c-Fms Function: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Subunit: Homodimer (isoform 2). Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Database links: UniProtKB/Swiss-Prot: P49771.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Flt3L是一种可以促进多种干细胞、血细胞及其前体细胞生成、分化的细胞因子,对T淋巴细胞、B淋巴细胞和NK细胞和DC的前体细胞都有促进增生、诱导分化的功能.Flt3L可与其它促细胞生长的细胞因子有很好的协同作用.目前,尚未发现具有毒性作用,是一种良好的扩增剂,对研究细胞的形态、细胞表现型和功能具有重要的意义 |
FLT 3配体（FLT 3-L），不同的FLT 3／FLK 2配体或FL，是一种造血生长因子，刺激干细胞和CD34+祖细胞的增殖，并已从小鼠和人类基因组中克隆。FLT 3-L是粒细胞-巨噬细胞集落刺激因子（GM-CSF）、白细胞介素-3（IL-3）和G-CSF依赖的粒细胞-巨噬细胞前体来源于LIN CD34+骨髓细胞以及其他原始B细胞群体的体外生长刺激剂。此外，FLT 3-L刺激从小鼠胎肝或成年小鼠骨髓分离的造血祖细胞的增殖。然而，FLT 3-L不影响红系定向祖细胞的生长。FLT 3-L存在于两种形式中，并且作为可溶性和膜结合配体都是活性的。FLT 3-L受体FLT 3是在CD34+细胞上表达的酪氨酸激酶，与SCF（干细胞因子）受体、c-kit和c-FMS具有高度同源性。