FITC标记的G蛋白偶联受体58抗体
产品名称： FITC标记的G蛋白偶联受体58抗体
英文名称： Anti-GPR58/FITC
产品编号： HZ-13541R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GPR58/FITC Conjugated antibody
FITC标记的G蛋白偶联受体58抗体
| 英文名称 | Anti-GPR58/FITC |
| 中文名称 | FITC标记的G蛋白偶联受体58抗体 |
| 别 名 | GPCR GPR58; G protein coupled receptor 58; phBL5; GPCR 58; GPR 58; TAAR2; Trace amine associated receptor 2; TAAR2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转录调节因子 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPR58 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Trace amines are endogenous molecules structurally related to classical biogenic amines that are linked to psychiatric conditions. A family of G-protein coupled receptors referred to as trace-amine-associated receptors (TAAR) are activated by trace amines and are present in very low levels in mammalian tissue. TAAR’s contain several structural features that are similar to the rhodopsin beta-adrenergic receptor superfamily, including the positions of the seven transmembrane regions that provide common ligand-binding pockets as well as the short N- and C-terminal domains. TAAR proteins are potential targets for drugs of abuse, such as amphetamine and MDMA, as well as neuropsychiatric disorders including schizophrenia, depression, and attention deficit disorder. TAAR-1 is a 340 amino acid protein that increases intracellular cAMP accumulation in response to beta-phenylethylamine and tyramine. TAAR-1 is associated with the detection of social cues, illustrating its significance as a therapeutic target. Function: G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. GPCR GPR58 is a member of this family (subfamily Orphan-A). GPR58 expression has not been reported from human liver and several brain areas. Subcellular Location: Integral membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 9287 Human Omim: 604849 Human SwissProt: Q9P1P5 Human Unigene: 272382 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
痕量胺是结构上与经典的生物胺相关的内源性分子，与精神疾病有关。G蛋白偶联受体家族称为微量胺相关受体（TAAR），由微量胺激活，在哺乳动物组织中含量非常低。TAAR包含几个与视紫红质β-肾上腺素能受体超家族相似的结构特征，包括七个跨膜区域的位置，这些区域提供共同的配体结合口袋以及短的N-末端和C-末端结构域。TAAR蛋白是药物滥用的潜在靶点，如***和MDMA，以及包括精神分裂症、抑郁症和注意缺陷障碍在内的神经精神疾病。TAAR-1是一种340种氨基酸蛋白，能增加β-苯乙胺和酪胺对细胞内cAMP的积累。TAAR-1与检测社会线索相关，说明其作为治疗靶点的意义。