FITC标记的细胞粘附分子3抗体
产品名称： FITC标记的细胞粘附分子3抗体
英文名称： Anti-CADM3/FITC
产品编号： HZ-6027R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CADM3/FITC Conjugated antibody
FITC标记的细胞粘附分子3抗体
| 英文名称 | Anti-CADM3/FITC |
| 中文名称 | FITC标记的细胞粘附分子3抗体 |
| 别 名 | Brain immunoglobulin receptor; Synaptic cell adhesion molecule 3; Necl 1; synCAM3; CADM 3; Cell adhesion molecule 3; FLJ10698; IGSF4B; Immunoglobulin superfamily member 4B; NECL1; Nectin like protein 1; TSLC1 like protein 1; TSLL1; CADM3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 细胞粘附分子 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CADM3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Immunoglobulin superfamily member 4B (Cell adhesion molecule 3, Nectin-like protein 1) is a nectin family gene product that contains 2 Ig-like C2-type (immunoglobulin-like) domains and an Ig-like V-type (immunoglobulin-like) domain. IGSF4B is a single-pass type I membrane protein that localizes to cell-cell interacting sites along the plasma membrane. IGSF4B functions as a cell adhesion molecule at cell-cell junctions. IGSF4B can be found as a homodimer and has a dual calcium-independent adhesion function; a homophilic cell-cell interaction and a heterophilic cell-cell interaction involving IGSF4, Nectin 1 and Nectin 3. IGSF4B may also interact with EPB41L1 which has a potential for regulating structure or function of cell-cell junctions By similarity. Isoform 1 is expressed in adult and fetal brain. Isoform 2 is highly expressed in the cerebellum but is also weakly expressed in placenta. IGSF4B has been found to be markedly over-expressed in glioma cell lines and prostate cancer cell lines. Function: Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions. Subunit: Homodimer. Can form trans-heterodimers with PVRL3/nectin-3. Interacts with EPB41L1, DLG3, MPP6 and CASK. Subcellular Location: Cell junction. Cell membrane. Localized at the cell-cell attached sites of the plasma membrane. Tissue Specificity: Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. Similarity: Belongs to the nectin family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: Entrez Gene: 57863 Human Entrez Gene: 94332 Mouse Entrez Gene: 360882 Rat Omim: 609743 Human SwissProt: Q8N126 Human SwissProt: Q99N28 Mouse SwissProt: Q1WIM3 Rat Unigene: 365689 Human Unigene: 330524 Mouse Unigene: 138884 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
免疫球蛋白超家族成员4B（细胞粘附分子3，Nexin样蛋白1）是包含2 Ig类C2型（免疫球蛋白样）结构域和Ig类V型（免疫球蛋白样）结构域的内含子家族基因产物。IGFSF4B是一种单程I型膜蛋白，定位于质膜上的细胞-细胞相互作用位点。IGFSF4B作为细胞黏附分子在细胞-细胞连接处起作用。IGSF4B可以被发现为同源二聚体，具有双钙独立的粘附功能；嗜同种细胞-细胞相互作用和嗜异细胞-细胞相互作用，涉及IGFSF4、NECTIN 1和NECTIN 3。IGFSF4B也可以与EPB41L1相互作用，其具有通过相似性调节细胞-细胞连接的结构或功能的潜力。异构体1在成人和胎儿脑中表达。异构体2在小脑中高表达，但在胎盘中也弱表达。IGFSF4b在胶质瘤细胞系和前列腺癌细胞系中的表达量明显高于对照组。