MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Carbamazepine
CAS No. : 298-46-4
MCE 国际站：Carbamazepine
产品活性：Carbamazepine 是一种具有口服活性的压敏钠离子通道阻断剂，IC50 为 131 μM。Carbamazepine 可阻断电压门控 Na+、Ca2+ 和 K+ 通道，也是一种 HDAC 抑制剂 (IC50: 2 μM)。Carbamazepine 是一种抗惊厥试剂，可用于癫痫和神经性疼痛的研究。
研究领域：Membrane Transporter/Ion Channel | Autophagy | Neuronal Signaling | Epigenetics | Cell Cycle/DNA Damage
作用靶点：Sodium Channel | Autophagy | Mitophagy | Potassium Channel | Calcium Channel | HDAC
In Vitro: Carbamazepine (0-500 μM, 10 days) inhibits pre-adipocyte differentiation (10 days) and triglyceride accumulation (7 days) in 3T3-L1, 3T3-F442A and T37i cells.
Carbamazepine (5-20 μM, 15 min before LPS) inhibits LPS-induced production of NO and iNOS protein, and phosphorylation of Akt in microglial (BV-2) cells.
Carbamazepine (20 μM, 15 min before LPS) inhibits LPS-induced COX-2 expression and TNF-α production in microglial (BV-2) cells.
In Vivo: Carbamazepine (250 mg/kg, p.o.) promotes liver regeneration and survival in partial hepatectomy (PHx) treated mice.
Carbamazepine (0.25%-0.75% for ICR mice, 0.5% and 0.75% for C57bl/6 mice with, in food (w/w)) shows mood-stabilising effects in mice.
相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Antiviral Compound Library | CNS-Penetrant Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Alzheimer's Disease Compound Library | Neuroprotective Compound Library | Anti-Breast Cancer Compound Library | Drug-Induced Liver Injury (DILI) Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Neurodegenerative Disease-related Compound Library | Mitochondria-Targeted Compound Library | Targeted Diversity Library | Anti-Liver Cancer Compound Library | Rare Diseases Drug Library | Children’s Drug Library | Calcium Channel Blocker Library | Sodium Channel Blocker Library | Potassium Channel Compound Library | FDA-Approved Anticancer Drug Library | Human Metabolite Library | Osteogenesis Compound Library | Off-patent Drug Library | Mitochondrial Protection Compound Library | Antihypertensive Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Cell Death Library | Ion Channel Compound Library | Anti-Hematopathy Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | 3-Methyladenine | Doxorubicin hydrochloride | Olaparib | Dexamethasone | Etoposide | Mdivi-1 | Ruxolitinib | Brefeldin A | Adezmapimod | Nigericin sodium salt | Metformin | Quercetin | Trichostatin A | Thapsigargin | L-Ascorbic acid | Ionomycin | AICAR | Resveratrol | Yoda 1 | Curcumin | 4-Phenylbutyric acid | Vorinostat | Simvastatin | Melatonin | Valproic acid | BAPTA-AM | Sulforaphane | Hemin | U0126-EtOH | Sunitinib
热门产品线：重组蛋白 | 药物筛选 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
• 提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。
